Effects of contact location and voltage amplitude on speech and movement in bilateral subthalamic nucleus deep brain stimulation
Identifieur interne : 002878 ( Main/Exploration ); précédent : 002877; suivant : 002879Effects of contact location and voltage amplitude on speech and movement in bilateral subthalamic nucleus deep brain stimulation
Auteurs : Elina Tripoliti [Royaume-Uni] ; Ludvic Zrinzo [Royaume-Uni] ; Irene Martinez-Torres [Royaume-Uni] ; Stephen Tisch [Royaume-Uni] ; Eleanor Frost [Royaume-Uni] ; Ellie Borrell [Royaume-Uni] ; Marwan I. Hariz [Royaume-Uni] ; Patricia Limousin [Royaume-Uni]Source :
- Movement Disorders [ 0885-3185 ] ; 2008-12-15.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
- Acoustics, Aged, Amplitude, Analysis of Variance, Antibodies, Monoclonal, Biophysical Processes, Deep Brain Stimulation (methods), Deep brain stimulation, Female, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Movement (physiology), Nervous system diseases, Neurologic Examination, Neuropsychological Tests, Parkinson Disease (physiopathology), Parkinson Disease (therapy), Recombinant Fusion Proteins, Severity of Illness Index, Speech, Speech (physiology), Subthalamic Nucleus (physiology), Subthalamic nucleus, Voltage, contact location, deep brain stimulation, electrical parameters, speech.
- MESH :
- chemical : Antibodies, Monoclonal, Recombinant Fusion Proteins.
- methods : Deep Brain Stimulation.
- physiology : Movement, Speech, Subthalamic Nucleus.
- physiopathology : Parkinson Disease.
- therapy : Parkinson Disease.
- Acoustics, Aged, Analysis of Variance, Biophysical Processes, Female, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Neurologic Examination, Neuropsychological Tests, Severity of Illness Index.
Abstract
Subthalamic nucleus deep brain stimulation (STN‐DBS) is particularly effective in improving limb symptoms in Parkinson's disease. However, speech shows a variable response. Contact site and amplitude of stimulation have been suggested as possible factors influencing speech. In this double blind study, we assessed 14 patients post bilateral STN‐DBS, without medication. Six conditions were studied in random order as follows: stimulation inside the STN at low voltage (2 V) and at high voltage (4 V); above the STN at 2 V and at 4 V, at usual clinical parameters, and off‐stimulation. The site of stimulation was defined on the postoperative stereotactic MRI data. Speech protocol consisted of the assessment of intelligibility of the dysarthric speech, maximum sustained phonation, and a 1‐minute monologue. Movement was assessed using the UPDRS‐III. Stimulation at 4 V significantly reduced the speech intelligibility (P = 0.004) independently from the site of stimulation. Stimulation at 4 V significantly improved the motor function. Stimulation inside the nucleus was significantly more effective than outside the nucleus (P = 0.0006). The significant improvement in movement coupled with significant deterioration in speech intelligibility when patients are stimulated inside the nucleus at high voltage indicates a critical role for electrical stimulation parameters in speech motor control. © 2008 Movement Disorder Society
Url:
DOI: 10.1002/mds.22296
Affiliations:
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Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2008-12-15">2008-12-15</date><biblScope unit="vol">23</biblScope><biblScope unit="issue">16</biblScope><biblScope unit="page" from="2377">2377</biblScope><biblScope unit="page" to="2383">2383</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">57B2BE51607F176DCCE6708B9211E73D6DD24720</idno><idno type="DOI">10.1002/mds.22296</idno><idno type="ArticleID">MDS22296</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Acoustics</term><term>Aged</term><term>Amplitude</term><term>Analysis of Variance</term><term>Antibodies, Monoclonal</term><term>Biophysical Processes</term><term>Deep Brain Stimulation (methods)</term><term>Deep brain stimulation</term><term>Female</term><term>Humans</term><term>Magnetic Resonance Imaging</term><term>Male</term><term>Middle Aged</term><term>Movement (physiology)</term><term>Nervous system diseases</term><term>Neurologic Examination</term><term>Neuropsychological Tests</term><term>Parkinson Disease (physiopathology)</term><term>Parkinson Disease (therapy)</term><term>Recombinant Fusion Proteins</term><term>Severity of Illness Index</term><term>Speech</term><term>Speech (physiology)</term><term>Subthalamic Nucleus (physiology)</term><term>Subthalamic nucleus</term><term>Voltage</term><term>contact location</term><term>deep brain stimulation</term><term>electrical parameters</term><term>speech</term></keywords><keywords scheme="MESH" type="chemical" xml:lang="en"><term>Antibodies, Monoclonal</term><term>Recombinant Fusion Proteins</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Deep Brain Stimulation</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Movement</term><term>Speech</term><term>Subthalamic Nucleus</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Acoustics</term><term>Aged</term><term>Analysis of Variance</term><term>Biophysical Processes</term><term>Female</term><term>Humans</term><term>Magnetic Resonance Imaging</term><term>Male</term><term>Middle Aged</term><term>Neurologic Examination</term><term>Neuropsychological Tests</term><term>Severity of Illness Index</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Amplitude</term><term>Noyau sousthalamique</term><term>Parole</term><term>Pathologie du système nerveux</term><term>Stimulation cérébrale profonde</term><term>Tension électrique</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Subthalamic nucleus deep brain stimulation (STN‐DBS) is particularly effective in improving limb symptoms in Parkinson's disease. However, speech shows a variable response. Contact site and amplitude of stimulation have been suggested as possible factors influencing speech. In this double blind study, we assessed 14 patients post bilateral STN‐DBS, without medication. Six conditions were studied in random order as follows: stimulation inside the STN at low voltage (2 V) and at high voltage (4 V); above the STN at 2 V and at 4 V, at usual clinical parameters, and off‐stimulation. The site of stimulation was defined on the postoperative stereotactic MRI data. Speech protocol consisted of the assessment of intelligibility of the dysarthric speech, maximum sustained phonation, and a 1‐minute monologue. Movement was assessed using the UPDRS‐III. Stimulation at 4 V significantly reduced the speech intelligibility (P = 0.004) independently from the site of stimulation. Stimulation at 4 V significantly improved the motor function. Stimulation inside the nucleus was significantly more effective than outside the nucleus (P = 0.0006). The significant improvement in movement coupled with significant deterioration in speech intelligibility when patients are stimulated inside the nucleus at high voltage indicates a critical role for electrical stimulation parameters in speech motor control. © 2008 Movement Disorder Society</div></front></TEI><affiliations><list><country><li>Royaume-Uni</li></country><region><li>Angleterre</li><li>Grand Londres</li></region><settlement><li>Londres</li></settlement></list><tree><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Tripoliti, Elina" sort="Tripoliti, Elina" uniqKey="Tripoliti E" first="Elina" last="Tripoliti">Elina Tripoliti</name></region><name sortKey="Borrell, Ellie" sort="Borrell, Ellie" uniqKey="Borrell E" first="Ellie" last="Borrell">Ellie Borrell</name><name sortKey="Frost, Eleanor" sort="Frost, Eleanor" uniqKey="Frost E" first="Eleanor" last="Frost">Eleanor Frost</name><name sortKey="Hariz, Marwan I" sort="Hariz, Marwan I" uniqKey="Hariz M" first="Marwan I." last="Hariz">Marwan I. Hariz</name><name sortKey="Limousin, Patricia" sort="Limousin, Patricia" uniqKey="Limousin P" first="Patricia" last="Limousin">Patricia Limousin</name><name sortKey="Martinez Orres, Irene" sort="Martinez Orres, Irene" uniqKey="Martinez Orres I" first="Irene" last="Martinez-Torres">Irene Martinez-Torres</name><name sortKey="Tisch, Stephen" sort="Tisch, Stephen" uniqKey="Tisch S" first="Stephen" last="Tisch">Stephen Tisch</name><name sortKey="Zrinzo, Ludvic" sort="Zrinzo, Ludvic" uniqKey="Zrinzo L" first="Ludvic" last="Zrinzo">Ludvic Zrinzo</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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